Polypodium Leucotomos

Polypodium leucotomos

Polypodium leucotomos extract (PLE) is a natural substance of plant origin extracted from ferns growing in Central America.


Our cultivation and extraction process guarantees optimal quality and efficiency: Polypodium leucotomos is cultivated on specific dates on experimental and recovered estates in Guatemala; where it undergoes primary stabilisation by dehydration under controlled conditions. It is then sent to Spain where it is processed and standardised in our extraction plant according to European Union GMP regulations and stringent quality standards.

All our extraction and production procedures are propriety and patented by Asacpharma, and safeguard the chemical integrity of all its components.


In ancient times, Polypodium leucotomos was used as a folk remedy to treat numerous diseases such as asthma and heart disease.

We started growing PLA in Guatemala.

In 1983, an immunomodulatory effect was first described.

We have been using PLE in different pharmaceutical products for over 40 years: Prescription drugs, food supplements and cosmetics. It is a highly effective treatment with multiple benefits.

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Especialidades Farmacéuticas CENTRUM, S.A.

RGSEAA: 26.09272/A

C/ Sagitario, 14. 03006 Alicante - España